Biotechnology & Genomics R&D in Pakistan

Complete gene mapping of a Pakistani citizen by Human Genome Project in Karachi has put the country on a very short list of nations which have accomplished this scientific feat. To assess the state of genomics and biotechnology in Pakistan, let's take a look at what is happening in the country in this field:

1. Researchers at the Panjwani Center for Molecular Medicine and Drug Research (PCMD) in Karachi collaborated with Beijing Genomics Institute (BGI) to complete gene mapping of Dr. Ata-ur-Rahman, according to SciDev. Dr. Rehman, President of Pakistan Academy of Sciences, volunteered himself for the project.

2. More than two hundred life sciences departments are engaged in genomics and biotechnology research at various Pakistani universities, according to a report in The News.

3. Pakistan has been a Science Watch rising star for several years for research papers in multiple fields, particularly in biological sciences. Publications by Pakistani research teams have increased four-folds in the last decade, and the majority of publications from major universities are in life sciences.

4. Pakistan began producing biotechnology based pharmaceuticals in 2009. The first of these plants was set up by Ferozesons in Lahore to produce interferon for treatment of hepatitis, according to Nature magazine.

5. Pakistan has significant research efforts in seed and livestock development at various agriculture universities, institutes and departments. Pakistani researchers and scientists are currently collaborating in life sciences with their counterparts in the US and China. A number of crops like cotton, rice, wheat, corn, potato, ground nut are being developed locally or with the collaboration of Chinese and US seed companies.

6. Post-doctoral research on biotechnology and related agricultural issues is being funded under a Young Scientists Program, as part of the USDA-funded sustainable endowment to support the Agricultural Linkages Program at the Pakistan Agricultural Research Council (PARC). An MOU for $7.5 million has been signed under the Pakistan-U.S. Science and Technology Program between Pakistan’s Higher Education Commission (HEC) and the Ministry of Science and Technology and the U.S Agricultural Research Service (ARS) for scientific collaboration and capacity building of scientists.

7. National Biosafety Committee has allowed stacked gene (Cry 1A and Cry 2Ab) in cotton developed by Center of Excellence in Molecular Biology (CEMB), Lahore. Several other stacked gene products are in the pipe line and will be put for approval soon.

8. Pakistan is building the capacity of its young scientists in the legislative, regulatory, and policy areas related to agricultural biotechnology, biosafety and nanotechnology. A small project has been funded in Agricultural Nanobiotechnology related to the use of nanoparticles for plant genetic engineering utilizing a Bio-Rad biolistic gene gun at National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad.

While the universities have stepped up their research programs in life sciences as a result of the higher education reforms undertaken in the last decade, it's still a major challenge to translate the academic work into tangible benefits in terms of improved human health and higher crop and livestock yields in the country.

Part of the challenge stems from the need for regulatory framework for introducing biotech products and technology for humans, plants and animals. To make progress on this front, Pakistan has ratified the Cartagena Protocol of Biosafety (CPB) with a framework for handling GMO’s. The proposed regulatory guidelines are built upon on a three-tier system composed of the National Biosafety Committee (NBC); a Technical Advisory Committee (TAC); and Institutional Biosafety Committees (IBC), according to USADA GAIN report on Pakistan.

In the regulatory framework, the Secretary of the Ministry of Environment heads the NBC, and is responsible for oversight of all laboratory work and field trials, as well as authorizing the commercial release of GM products. The three monitoring and implementing bodies administer enforcement of the National Biosafety Guidelines. The IBC may make recommendations to the NBC regarding the awarding of exemptions for laboratory and fieldwork related to products of bioengineering. These recommendations may be accepted, and formal approval granted, if sufficient information and grounds exist to consider the risk as being minimal or non-existent. After permission for deregulation is granted by the NBC, approval can still be withdrawn provided sufficient technical data and other evidence later becomes available that warrants a review. The other important ministry dealing with production and release of GM crop is Ministry of Food and Agriculture (MINFA). The ministry developed several Standard Operating Procedures (SOP’s) for handling of cases of import/approval/release of GM crops; however, all these have yet to be promulgated.

Genomics and biotechnology have great potential to fight diseases and help improve human lives and increase productivity. So far, the benefits of these advances have accrued mostly to the rich countries because they are driven by market incentives. The time has now come for Pakistan to take advantage of such technological advances. Take crop yields as an example. Wheat is the staple of Pakistan and planted on the largest acreage. It contributes about three percent to the GDP. The national average yield is about 2.7 tons per hectare, far below the average in European countries such as France, Germany and the United Kingdom where they are above seven tons per hectare, according to recent Op Ed by Dr. Ata-ur-Rehman.

There is significant opposition to the use of GM seeds in South Asia today. In his book The Rational Optimist, author Matt Ridley recalls that there was similar resistance in 1960s to Nobel Laureate Norman Borlaug's Mexican dwarf wheat. Ridley writes about how Borlaug's efforts helped spark the Green Revolution in India and Pakistan. Ridley argues that it was Borlaug's work with his new seeds and chemical fertilizer that disproved Paul Ehrlich's claim in his book The Population Bomb that India would never feed itself.

Pakistani farmers have already begun planting biotech cotton since 2011. With 2.6 million hectares of Bt cotton planted in 2011, Pakistan ranks 8th in terms of the area for biotech crops in the world, according to International Service for the Acquisition of Agri-Biotech Applications (ISAAA) report. US ranks number 1, Brazil 2, Argentina 3, India 4, Canada 5, China 6, Paraguay 7 and Pakistan 8. South Africa 9 and Uruguay 10 round out the top 10. Pakistan has had a bumper crop of cotton in 2011-2012 mainly because of the planting of Bt seeds.

While extra caution is absolutely warranted before introducing genetically modified organisms in the environment, an irrational fear of the unknown would be unacceptable in a country like Pakistan with its dwindling water resources and a growing young population that needs to be fed, clothed, educated and nurtured. Clearly, the technology can help cure diseases and lead to development of new drought-resistant seed varieties producing high crop yields.

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Views: 1277

Comment by Riaz Haq on April 17, 2021 at 6:48pm

#Pakistani, #Chinese firms to make #coronavirus jab in #Pakistan . Searle Pakistan will be the first company to manufacture a #COVID19 #vaccine in Pakistan, said the jab has shown promising results in Phase 1 and 2 trials. #pandemic #pharmaceutical

https://www.aa.com.tr/en/asia-pacific/pakistani-chinese-firms-to-ma...

A Pakistani pharmaceutical company has signed a deal with a Chinese firm to produce a COVID-19 vaccine in the country, according to an official announcement on Thursday.

In a letter to the Pakistan Stock Exchange, Searle Company Limited said it had finalized an agreement with China’s Livzon Mapharm Inc. to manufacture a novel coronavirus vaccine – V-01 – in Pakistan.

“The Searle Company Limited has successfully concluded an exclusive licensing and supply agreement with Livzon Mapharm Inc. for the Recombinant Novel Coronavirus Vaccine (V-01),” read the letter.

“The licensing agreement also covers the manufacturing transition of (V-01) in Pakistan.”

Searle, which will be the first company to manufacture a COVID-19 vaccine in Pakistan, said the jab has shown promising results in Phase 1 and 2 trials.

“The Phase Ill clinical study will include multiple countries and enroll more than 20,000 subjects, with the aim to evaluate the efficacy, safety, and immunogenicity of V-01 program,” the letter said.

According to the company, the vaccine has “many potential advantages such as strong safety profile … long durability, and easy to scale up for manufacturing.”

Searle said it was hopeful that “the relevant authorities will take up the matter on urgent basis and support fast-track approval to carry out Phase 3 clinical trials in Pakistan.”

Pakistan has so far approved four COVID-19 vaccines for use in the country – China’s Sinopharm and CanSino, along with Russia’s Sputnik V and the Oxford-AstraZeneca jab.


Infections hitting new highs

Pakistan on Friday reported 5,234 new COVID-19 cases, the highest daily spike since June 20 last year, raising its overall tally to 678,165.

Another 83 patients died in the last 24 hours, pushing the fatality count to 14,613, according to the Health Ministry.

As many as 607,205 patients have recovered so far, leaving the number of active cases at 56,347, latest data showed.

Infections have surged in the South Asian country of over 200 million in recent days, with more than 75,000 reported in March alone.

Asad Umar, the country’s planning minister who is leading its pandemic response, said the entire region has been experiencing a “severe” COVID-19 spike.

“It is vital that we all contribute to containing the spread by taking sensible precautions. Wear a mask, avoid crowded places, wash hands or sanitize often, reduce travel to only essential work,” he said on Twitter.

As part of efforts to stem surging infections, the government has reimposed a blanket ban on all kinds of public gatherings across the country and is enforcing expanded lockdowns in the worst-hit areas.

Educational institutes have also been closed until at least April 11 in districts with high infection rates.

Comment by Riaz Haq on April 17, 2021 at 6:54pm

Pakistan inaugurates 1st science tech park
Move is step toward creating knowledge-based economy, says Prime Minister Imran Khan
Islamuddin Sajid |
09.12.2019

https://www.aa.com.tr/en/asia-pacific/pakistan-inaugurates-1st-scie...

Pakistani Prime Minister Imran Khan on Monday inaugurated the country's first science and technology park in the capital Islamabad.

It was established at the National University of Science and Technology, a leading higher education institution of the country.

"This is a big achievement and we are determined to turn Pakistan into a knowledge-based economy and innovation by utilizing the energies of youth at proper platforms," Khan said, addressing the inaugural ceremony aired on state-run Pakistan Television.

The project would extend to the other parts of the country as well, he added.

The park will host start-ups in diverse areas, particularly agriculture, health and smart technologies.

"This park will serve as a launchpad for the country’s leading researchers, innovators, and entrepreneurs," said Technology Minister Fawad Hussain.

Comment by Riaz Haq on June 11, 2023 at 7:19pm

Migration of academics: Economic development does not necessarily lead to brain drain

https://phys.org/news/2023-01-migration-academics-economic-necessar...

A team of researchers at the Max Planck Institute for Demographic Research (MPIDR) in Rostock, Germany, developed a database on international migration of academics in order to assess emigration patterns and trends for this key group of innovators. Their paper was published in PNAS on Jan. 18.

As a first step, the team produced a database that contains the number of academics who publish papers regularly, and migration flows and migration rates for all countries that include academics who published papers listed on the bibliographic database Scopus. The migration database was obtained by leveraging metadata of more than 36 million journal articles and reviews published from 1996 to 2021.

"This migration database is a major resource to advance our understanding of the migration of academics," says MPIDR Researcher Ebru Sanliturk. Data Scientist Maciej Danko adds: "While the underlying data are proprietary, our approach generates anonymized aggregate-level datasets that can be shared for noncommercial purposes and that we are making publicly available for scientific research."

MPIDR Researcher Aliakbar Akbaritabar explains how they processed the bibliographic data in order to receive information about the migration patterns of academics: "We used the metadata of the article title, name of the authors and affiliations of almost every article and review published in Scopus since 1996. We followed every single one of the roughly 17 million researchers listed in the bibliographic database through the years and noticed changes in affiliation and, by using that tactic we know how many academics left a given country every year."

The researchers' empirical analysis focused on the relationship between emigration and economic development, indicating that academic setting patterns may differ widely from population-level ones.

Previous literature has shown that, as low-income countries become richer, overall emigration rates initially rise. At a certain point the increase slows down and the trend reverses, with emigration rates declining.

This means that favoring economic development has the counterintuitive effect of initially increasing migration from low- and middle-income countries, rather than decreasing it.

Is this pattern also generally valid for migration of scientists?

Not really.

The researchers found that, when considering academics, the pattern is the opposite: in low- and middle-income countries, emigration rates decrease as the gross domestic product (GDP) per capita increases. Then, starting from around 25,000 US Dollars in GDP, the trend reverses and emigration propensity increases as countries get richer.

MPIDR Director Emilio Zagheni adds, "Academics are a crucial group of innovators whose work has relevant economic effects. We showed that their propensity to emigrate does not immediately increase with economic development—indeed it decreases until a high-income turning point and then increases. This implies that increasing economic development does not necessarily lead to an academic brain drain in low- and middle-income countries."

Unveiling these and related patterns, and addressing big scientific questions with societal implications, was possible only because of painstaking work in preparing this new global database of migration of academics. "We are putting the final touches on an even more comprehensive database, the Scholarly Migration Database, which will be released on its own website soon," says software developer Tom Theile.

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