Biotechnology & Genomics R&D in Pakistan

Complete gene mapping of a Pakistani citizen by Human Genome Project in Karachi has put the country on a very short list of nations which have accomplished this scientific feat. To assess the state of genomics and biotechnology in Pakistan, let's take a look at what is happening in the country in this field:

1. Researchers at the Panjwani Center for Molecular Medicine and Drug Research (PCMD) in Karachi collaborated with Beijing Genomics Institute (BGI) to complete gene mapping of Dr. Ata-ur-Rahman, according to SciDev. Dr. Rehman, President of Pakistan Academy of Sciences, volunteered himself for the project.

2. More than two hundred life sciences departments are engaged in genomics and biotechnology research at various Pakistani universities, according to a report in The News.

3. Pakistan has been a Science Watch rising star for several years for research papers in multiple fields, particularly in biological sciences. Publications by Pakistani research teams have increased four-folds in the last decade, and the majority of publications from major universities are in life sciences.

4. Pakistan began producing biotechnology based pharmaceuticals in 2009. The first of these plants was set up by Ferozesons in Lahore to produce interferon for treatment of hepatitis, according to Nature magazine.

5. Pakistan has significant research efforts in seed and livestock development at various agriculture universities, institutes and departments. Pakistani researchers and scientists are currently collaborating in life sciences with their counterparts in the US and China. A number of crops like cotton, rice, wheat, corn, potato, ground nut are being developed locally or with the collaboration of Chinese and US seed companies.

6. Post-doctoral research on biotechnology and related agricultural issues is being funded under a Young Scientists Program, as part of the USDA-funded sustainable endowment to support the Agricultural Linkages Program at the Pakistan Agricultural Research Council (PARC). An MOU for $7.5 million has been signed under the Pakistan-U.S. Science and Technology Program between Pakistan’s Higher Education Commission (HEC) and the Ministry of Science and Technology and the U.S Agricultural Research Service (ARS) for scientific collaboration and capacity building of scientists.

7. National Biosafety Committee has allowed stacked gene (Cry 1A and Cry 2Ab) in cotton developed by Center of Excellence in Molecular Biology (CEMB), Lahore. Several other stacked gene products are in the pipe line and will be put for approval soon.

8. Pakistan is building the capacity of its young scientists in the legislative, regulatory, and policy areas related to agricultural biotechnology, biosafety and nanotechnology. A small project has been funded in Agricultural Nanobiotechnology related to the use of nanoparticles for plant genetic engineering utilizing a Bio-Rad biolistic gene gun at National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad.

While the universities have stepped up their research programs in life sciences as a result of the higher education reforms undertaken in the last decade, it's still a major challenge to translate the academic work into tangible benefits in terms of improved human health and higher crop and livestock yields in the country.

Part of the challenge stems from the need for regulatory framework for introducing biotech products and technology for humans, plants and animals. To make progress on this front, Pakistan has ratified the Cartagena Protocol of Biosafety (CPB) with a framework for handling GMO’s. The proposed regulatory guidelines are built upon on a three-tier system composed of the National Biosafety Committee (NBC); a Technical Advisory Committee (TAC); and Institutional Biosafety Committees (IBC), according to USADA GAIN report on Pakistan.

In the regulatory framework, the Secretary of the Ministry of Environment heads the NBC, and is responsible for oversight of all laboratory work and field trials, as well as authorizing the commercial release of GM products. The three monitoring and implementing bodies administer enforcement of the National Biosafety Guidelines. The IBC may make recommendations to the NBC regarding the awarding of exemptions for laboratory and fieldwork related to products of bioengineering. These recommendations may be accepted, and formal approval granted, if sufficient information and grounds exist to consider the risk as being minimal or non-existent. After permission for deregulation is granted by the NBC, approval can still be withdrawn provided sufficient technical data and other evidence later becomes available that warrants a review. The other important ministry dealing with production and release of GM crop is Ministry of Food and Agriculture (MINFA). The ministry developed several Standard Operating Procedures (SOP’s) for handling of cases of import/approval/release of GM crops; however, all these have yet to be promulgated.

Genomics and biotechnology have great potential to fight diseases and help improve human lives and increase productivity. So far, the benefits of these advances have accrued mostly to the rich countries because they are driven by market incentives. The time has now come for Pakistan to take advantage of such technological advances. Take crop yields as an example. Wheat is the staple of Pakistan and planted on the largest acreage. It contributes about three percent to the GDP. The national average yield is about 2.7 tons per hectare, far below the average in European countries such as France, Germany and the United Kingdom where they are above seven tons per hectare, according to recent Op Ed by Dr. Ata-ur-Rehman.

There is significant opposition to the use of GM seeds in South Asia today. In his book The Rational Optimist, author Matt Ridley recalls that there was similar resistance in 1960s to Nobel Laureate Norman Borlaug's Mexican dwarf wheat. Ridley writes about how Borlaug's efforts helped spark the Green Revolution in India and Pakistan. Ridley argues that it was Borlaug's work with his new seeds and chemical fertilizer that disproved Paul Ehrlich's claim in his book The Population Bomb that India would never feed itself.

Pakistani farmers have already begun planting biotech cotton since 2011. With 2.6 million hectares of Bt cotton planted in 2011, Pakistan ranks 8th in terms of the area for biotech crops in the world, according to International Service for the Acquisition of Agri-Biotech Applications (ISAAA) report. US ranks number 1, Brazil 2, Argentina 3, India 4, Canada 5, China 6, Paraguay 7 and Pakistan 8. South Africa 9 and Uruguay 10 round out the top 10. Pakistan has had a bumper crop of cotton in 2011-2012 mainly because of the planting of Bt seeds.

While extra caution is absolutely warranted before introducing genetically modified organisms in the environment, an irrational fear of the unknown would be unacceptable in a country like Pakistan with its dwindling water resources and a growing young population that needs to be fed, clothed, educated and nurtured. Clearly, the technology can help cure diseases and lead to development of new drought-resistant seed varieties producing high crop yields.

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Comment by Riaz Haq on December 6, 2013 at 9:58pm

Here's a SciDev story on slow progress in nanotechnology research and development in Pakistan:

[KARACHI] Nanotechnology research in Pakistan, which had shown a trend of higher publication numbers over the last decade, has suffered from the country’s present financial crisis, a study said.

In 2008 the government did not extend the term of the National Commission for Nanoscience and Technology, initially set up in 2003 for three years and later extended for two more years.

The study, published online on 29 March in Scientometrics, said research publications in the field had grown from seven in 2000 to an impressive 542 papers in 2011, registering a 29 per cent annual growth rate.

This is higher than the average annual growth rate of 23 per cent registered globally, said Rizwan Sarwar Bajwa, research associate at the Preston Institute of Nanoscience and Technology in Islamabad who, together with his colleague Khwaja Yaldram, had carried out the study.

Much of the contribution came from 13 universities while only two state-owned research and development institutions in the country participated in nanoscience and nanotechnology research.

The study attributed the spurt in research and publications to heavy government spending on manpower training and procuring the latest equipment for laboratories working in the field.

"Unfortunately, the present financial crunch faced by the country could have a negative impact on the progress achieved so far," the study concluded.

"The publication shows that despite availability of funding, the research and development institutes contributed very little in the field of nanoscience and nanotechnology," Bajwa, lead author of the study, told SciDev.Net.

If developing countries such as Pakistan do not engage in basic research in nanoscience, they will end up as consumers of hi-tech products from other countries, he said.

http://www.scidev.net/global/technology/news/funds-crunch-hits-paki...

Comment by Riaz Haq on June 3, 2015 at 8:08am

Three US and four Pakistani universities have agreed to collaborate on research on energy, water and agriculture.

The US will provide $127 million for the establishment of the Centre for Advanced Studies (CAS).

The partnership will harness applied research and find innovative and practical solutions for Pakistan’s energy, water, and agriculture and food security challenges.

The details were revealed on Monday by a US embassy group at a roundtable discussion with journalists. Officials also shared details the upcoming inaugural meeting of Education, Science, and Technology Working Group (ESTWG).

The projects are to be launched on Wednesday at Planning Commission and National University of Science and Technology Islamabad and will be led by a US delegation along with Pakistani government officials.

While giving an overview of the programme, US Embassy Assistance Coordinator Brian Aggeler said the ESTWG is the sixth and newest working group under the US-Pak Strategic Dialogue, which is diplomatic framework for sustained engagement between both countries.

US Cultural Affairs Officer Judith Ravin said the programme is in line with the four Es of collaboration (economy, education, energy and extremism).

“It is an opportunity for these universities to maximise their capital and touch entire higher education sector,” Ravin said.

Under the CAS programme, the University of Agriculture Faisalabad and University of California, Davis will collaborate in agriculture and food security. In the energy sector, NUST and University of Engineering and Technology Peshawar will jointly work with the Arizona State University, while Mehran University of Engineering and Technology Jamshoro will work with the University of Utah for water projects.

USAID Education Office Deputy Director Garth Willis said revised curricula, financial assistance and laboratories will be established for the chosen universities through a competitive process.

Under the programme, scholarships, exchange programmes and leading networking activities will be provided. Similarly, construction, rehabilitation and up-gradation of CAS facilities are also part of the programme.

http://tribune.com.pk/story/895981/collaboration-us-pak-universitie...

Comment by Riaz Haq on July 12, 2015 at 8:56pm

Chinese Ambassador Sun Weidong has said that China would establish Bio‑Tech Research Laboratory in Pakistan under a joint venture programme to promote agriculture sector in the country.

The lab would offer excellent opportunities to carry out joint study and research and also enhance maximum cooperation between scientists of both countries, he said.

He called for maximum cooperation between the two countries in the fields of science, technology, agriculture and power sector.

Meanwhile Chinese Embassy sources here in Islamabad said Ambassador Sun paid a productive visit to Multan on July 10 and 11. He met Asad Ullah Khan, Commissioner of Multan and exchanged views on strengthening friendship and bilateral cooperation.

He paid site-visits to Fatima 2x60MW Bagasse Power Plant and encouraged the Chinese companies to participate in the construction of power projects in Pakistan. The Fatima 2x60MW Bagasse Power Plant constructed by Chinese contractor is applying advanced and environment-friendly technology, which will become a high-efficiency biomass power plant and add electricity to the Pakistani grid when being completed in 2016.

Ambassador Sun visited a Chinese Cotton Ginning Company and Multan Cotton Research Station. The Chinese Company aims to build a cotton industrial chain in Multan. The Multan Cotton Research Station is part of the China-Pakistan Joint Bio-Tech Laboratory. Chinese President Xi Jinping and Pakistani Prime Minister Nawaz Sharif witnessed the signing of the MoU of this Joint Laboratory in April this year.

The Research Station has bred 16 cotton varieties of antivirus, heat and drought tolerant species. The Ambassador said, Chinese side would like to seek the possibility to expand the agriculture cooperation between the two countries.

He reiterated China’s support to the China-Pakistan Economic Corridor, including infrastructure construction and production capacity cooperation. He called for cultural and people-to-people exchanges. He said that the Chinese side will provide Chinese government scholarship for students in Multan to study in China. He is fully convinced that the deep-rooted friendship between the two countries will be passed on from generation to generation.

Ambassador Sun also visited the culture and historical sites in Multan during his tour.

http://www.pakistantoday.com.pk/2015/07/13/city/islamabad/china-to-...

Comment by Riaz Haq on August 10, 2015 at 10:16pm

#chemistry Olympiad 2016 to be held in #Karachi #Pakistan http://www.dawn.com/news/1199665

KARACHI: Pakistan will host the 48th International Chemistry Olympiad (IChO) next year at the International Centre for Chemical and Biological Sciences (ICCBS), Karachi University (KU).

This was announced at a press conference held at the H.E.J. Research Institute of Chemistry, KU on Monday.

Around 300 young chemists and 150 experts from 75 countries are expected to participate in the international chemistry competition to be held from July 20 to 29, 2016.

The event will be jointly hosted by ICCBS-KU and the Higher Education Commission (HEC) Pakistan.

“Holding this prestigious global event in the country is an honour for the nation. The event will be held under foolproof security,” said president of the IChO 2016, Prof Atta-ur-Rahman.

Comment by Riaz Haq on November 25, 2015 at 8:32pm

#China to build $1.5 billion science park in #Islamabad #Pakistan http://www.dailytimes.com.pk/national/25-Nov-2015/china-to-invest-1...

China on Wednesday agreed to invest $1.5 billion to set up Pakistan-China Science Park in Islamabad.

Minister for Science and Technology Rana Tanvir Hussain - who is on a visit to China - signed a memorandum of understanding (MoU) with his Chinese counterpart UN Urmaqi. He also invited the Chinese investers to visit Islamabad in next month to select location for construction of the Park by March 2016. He expressed his gratitude for huge investment in Pakistan.

The minister said that Pakistan and China had a lot to share with each other in term of technology, expertise and business. “We are looking to strengthen our mutual ties on economic as well as technological fronts,” he said, adding that this project would prove to be a link of the China-Pakistan Economic Corridor (CPEC). It would bring prosperity to the people of both sides.

Comment by Riaz Haq on January 9, 2016 at 7:28pm

MedCong: Medical corridor between #Pakistan and #China to collaborate in health sciences and serve the poor. #CPEC

http://tribune.com.pk/story/1024850/medcong-medical-corridor-betwee...

KARACHI: Medcong will serve as a medical corridor with China that will benefit poor patients in the two countries, said former federal minister and former Higher Education Commission chairperson Prof Attaur Rehman on Friday.

He was speaking at the inauguration of the first-ever three-day Pak-China Medical Congress (Medcong). The event, attended by senior medical experts of the two neighbouring countries, was inaugurated by Prof Rehman.

The Medcong, which is jointly being organised by Pakistan Medical Association (PMA) in collaboration with Chinese Medical Association (CMA), aims at paving the way for a medical corridor between Pakistan and China.

Addressing the ceremony, Prof Rehman said that Pakistan and China have strong high-level collaboration with each other. “The relations between both the countries have been improving day by day in various sectors, including education, research, medical, infrastructure building and other fields,” he said.

Prof Rehman said the establishment of a medical corridor with China will benefit the two countries’ poor patients. Tremendous opportunities exist for the medical students and researchers of the two countries, once provided with a chance to work together, he said.

CMA president Prof Yan Fei Liu said in his speech that Pakistan is magnificent, rich in natural resources and cultural heritage. “This ancient and magical land gave birth to a brilliant civilisation,” he said. “The Pakistani people are kind-hearted, hardworking, talented and courageous with the spirit of perseverance and [are] unyielding.”

According to him, CMA and PMA are going to make coherent efforts to build a Pak-China medical corridor to deepen the implementation of the China-Pakistan Economic Corridor and to seek bilateral exchanges and cooperation in medical education, patient caring, academia exchanges, medical information and experience sharing.

Prof Tipu Sultan, senior doctor and chairperson of the organising committee of Medcong said that China and Pakistan have been dear and close friends since long. “The academic and professional cooperation between the PMA and the CMA will bear great results,” he said.

A 44-member delegation representing the medical fraternity from China, including CMA vice-president and secretary-general Dr Keqin Rao, CMA deputy secretary-general Dr Lingo Lu, CMA international relations department deputy director Qing Long Meng and CMA project manager Weili Zhao are participating in the congress. The delegates, comprising medical experts from Sri Lanka, England and United Arab Emirates, are also participating in the congress along with their counterparts from different parts of Pakistan.

A memorandum of understanding (MoU) was also inked by the PMA and its Chinese counterpart, the CMA, during the congress. Both the PMA and CMA were declared sister concerns under the MoU while the decision to rotate the event every two years in the two countries will also be finalised.

Comment by Riaz Haq on September 16, 2016 at 10:08pm

The Force awakens
Salman Hameed TFT Issue: 09 Sep 2016
What is behind the flourishing amateur astronomy scene in Pakistan? Salman Hameed explains

http://www.thefridaytimes.com/tft/the-force-awakens/


Pakistan does not have an enviable record in the sciences. The current Nature Index for research output places Pakistan at number 52 – just between Georgia and Bulgaria. However, there is currently a thriving amateur astronomy scene in several Pakistani cities, where the love of the sciences and the joy of sharing the knowledge of the night sky are in full display. Later this month, the various amateur astronomy societies in the country will gather together to launch a new umbrella organisation, The Astronomical League of Pakistan (ALOP). Given the state of the education and the sciences in the country, it is worth exploring the reasons for this unqualified success.

I have been involved with and following the astronomy scene in Pakistan for close to thirty years. I was part of a group of FSc. Intermediate students in Karachi who started Amastropak, the first amateur astronomy society in Pakistan back in 1988. While there were ups and downs in the activities of the society over the years, it could never muster a critical mass of active members, and it eventually shut down in the late 1990s. But now things are different and I have never seen the state of amateur astronomy in Pakistan so lively and so strong. Last month I had the pleasure of meeting astronomy enthusiasts in Lahore and Karachi, and what a treat it was! Both the Lahore Astronomical Society (LAST) and the Karachi Astronomers Society (KAS) boast an active membership of well over a hundred each and they are passionate devotees of the night skies. Most of the members have day jobs unrelated to astronomy, but they squeeze every last second of their free time (or not so free time) for astronomy.

----------


Perhaps the biggest reason astronomy is flourishing is that there is now a committed community of astronomers around and they are eager to spread their own knowledge and passion. This community did not materialise overnight. No one guided the process. No one pressed for any direction. But there has been a thread of continuity, sometimes tenuous and sometimes strong, over the past three decades, and it is that thread that provided comfort in knowing that are others who share common interests across local space and local time.

Comment by Riaz Haq on July 27, 2017 at 4:42pm

#Pakistan’s 1st #hybrid #rice #research opens at International Centre for Chemical and Biological Sciences #Karachi https://www.thenews.com.pk/amp/219184-Countrys-first-hybrid-rice-re...

The vice chancellor of the University of Karachi, Professor Dr Muhammad Ajmal Khan, inaugurated the Sino-Pakistan Hybrid Rice Research Centre (SPHRRC) at the International Centre for Chemical and Biological Sciences (ICCBS), KU, on Wednesday.

The audience was informed that it was first of its kind centre in the country and had been set up at a cost of Rs150 million on the premises of the country’s leading research establishment of the ICCBS.

“The research centre has state-of-the-art research facilities, including NMR spectroscopes, plant tissue culture technology, genomics and greenhouses.” The curtain-opening ceremony was attended by ICCBS Patron-in-Chief Professor Dr Atta-ur-Rahman, Consul General of China in Karachi Wang Yu, China National Rice Research Institute (CNRRI) of Hangzhou’s Director General Professor Dr Cheng Shihua and ICCBS Director Professor Dr Muhammad Iqbal Choudhary.

Chinese Consul General Wang Yu said that Pakistan was famous for its high quality rice, while China was great importer of high quality Pakistani rice. Talking about the hybrid rice centre, he observed that the ICCBS owned highly qualified scholars and state-of-the-art research equipment.

Comment by Riaz Haq on August 16, 2018 at 10:08am

Mutant Varieties Satisfy Market and add USD 6 Billion to Pakistan’s Economy

https://www.iaea.org/newscenter/news/mutant-varieties-satisfy-marke...

When Pakistani farmers harvested fields planted with a new mutant variety of cotton, not only did they have a higher yield, they also received a higher price at the market because of the improved fibre quality. Farmers who adopted mutant varieties of sesame released in 2016 saw yields double and income increase, and now these new varieties cover 50 percent of the area planted to sesame in the entire country. Those who planted a mutant variety of castor bean released in 2017, bred for early maturity and high oil content, have already planted it on 2 000 ha and are making an extra USD 618 per ha. These are just a few of dozens of advances made possible by Pakistan’s Nuclear Institute for Agriculture and Biology (NIAB) which, with the support of the Joint FAO/IAEA Division, has used mutation breeding to improve varieties of eight different crops – benefitting millions of Pakistani farmers and their families, and adding billions to the Pakistan economy.

Across the millennia, those entrusted with saving seeds for planting in future seasons have always made decisions related to the environment, choosing seeds from varieties that will give them the best chance of a good harvest. Even as science has advanced the field from simply saving seeds to cross breeding and now to mutation breeding, the crucial role of the plant breeder has remained largely unchanged – developing varieties that can thrive in whatever the local environment has to offer and be resilient enough to adapt to change. Since 1969, Pakistan’s Nuclear Institute for Agriculture and Biology (NIAB), an institute of the Pakistan Atomic Energy Commission, has overseen the development of 43 mutant crop varieties, ranging from sesame seed to castor bean to mandarin to cotton – all bred in response to what Pakistan’s farmers and their consumers need.

The government of Pakistan recognizes the importance of breeding crop varieties specifically for the Pakistan situation – its terrain, its climate, the needs and capacities of its farmers and, of course, when it comes to food crops, the taste and texture that will appeal to consumers. This government support of the NIAB mutant breeding programme has paid back in terms of increased yields and higher quality products, which have not only contributed to farmers’ livelihoods, it has meant more food for the marketplace and improved food security. Two sesame varieties released in 2016 and 2017 have double the yield of traditional varieties and are more suitable for modern cultivation techniques. The mutant mandarin variety, NIAB Kinnow, released in 2017, has an increased yield of more than 30 percent and reduced seed count from around 50 to just 3-5 seeds per fruit, which makes it more valuable and popular for export.

NIAB has received support from the Joint Division for more than 30 years, including equipment and technology packages for mutation breeding, individual staff trainingthrough fellowships, and national and regional training courses. The mutation breeding process calls for irradiating and then planting crop seeds, and then screening them as they grow in the following generations to see which induced changes that emerge could be helpful for breeding in future generations – from aesthetics of colour and texture to physiological changes that account for traits such as heat or cold tolerance, resilience or length of the growing period.

Comment by Riaz Haq on April 17, 2021 at 6:48pm

Pakistan to make single-dose Covid vaccine
Chinese team to help scientists, NIH official tells NA penal


https://tribune.com.pk/story/2294652/pakistan-to-make-single-dose-c...

An official told a National Assembly panel on Tuesday that the National Institute of Health (NIH) is going to make Pakistan’s own single-dose coronavirus vaccine soon. “We are going to make a single-dose vaccine for Covid-19,” NIH Executive Director Major General Aamer Ikram told the NA Standing Committee on National Health Services. “We conducted the clinical trial of Chinese Covid-19 vaccine CanSinoBio in Pakistan.

The tests that were first conducted on 300 subjects are now administered in more than 150,000 laboratories,” he added. Later talking to the media, Major General Ikram said Pakistan was among the first countries to take part in the clinical trial of CanSinoBio vaccine. “Pakistan had requested China to transfer the technology for the vaccine. The raw material for the vaccine is going to arrive this month. “We hope that we will be able to take some measures for preparation of the vaccine by the end of April. The NIH has procured all the equipment and chemicals needed in this regard.

“Our team is ready to undertake this task while a Chinese team has also arrived in Pakistan. The Chinese team will oversee our team at the NIH,” he said. Earlier briefing the parliamentary panel, Maj Gen Ikram said the NIH Act is also being amended to restructure the organization and make it more vibrant. “Under the new law, there will be seven executive directors and one chief executive director. Employees of the departments merged with the NIH will be able to get a golden handshake within three months.”

He said the NIH has now set up a disease center in every district of the country. The plant which was closed a few years back has been made functional again. “Once the new plant is ready, the process for manufacturing the Covid vaccine will begin. The NIH is going to make its own single-dose vaccine in the near future,” the official said. He said the NIH does not get any funds from the Ministry of Health. “We spent Rs20 million on salaries. All the experts have been included in the NIH board,” he added.

The NA committee lauded the NIH’s efforts and declared it good news for the nation. Special Assistant to the Prime Minister on Health Faisal Sultan told the committee that Prime Minister Imran Khan has directed him to resolve the issue of three government hospitals in Karachi in consultation with the provincial government of Sindh. “If the Sindh government wants to run the hospitals, then we have no objections. We are bound to follow the Supreme Court’s orders. Now we will work together to find a solution in accordance with the law. We want to further improve the institutions,” Sultan said.

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